151379-88-3Relevant academic research and scientific papers
Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure
Davies, Stephen G.,Fletcher, Ai M.,Hughes, Deri G.,Lee, James A.,Price, Paul D.,Roberts, Paul M.,Russell, Angela J.,Smith, Andrew D.,Thomson, James E.,Williams, Oliver M.H.
, p. 9975 - 9992 (2012/02/15)
The conjugate addition of an enantiopure lithium amide to a ζ-hydroxy-α,β-unsaturated ester followed by a one-pot ring-closure/N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts), and (R,R)-1-(hydroxymethyl)octahydroindolizine (the bicyclic fragment of stellettamides A-C).
Asymmetric synthesis of piperidines and octahydroindolizines
Davies, Stephen G.,Hughes, Deri G.,Price, Paul D.,Roberts, Paul M.,Russell, Angela J.,Smith, Andrew D.,Thomson, James E.,Williams, Oliver M.H.
scheme or table, p. 567 - 570 (2010/09/09)
The conjugate addition of a homochiral lithium amide to a ξ-hydroxy-α,β-unsaturated ester, followed by a one-pot, ring-closure-N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts) and the bicyclic core of stellettamide A. Georg Thieme Verlag Stuttgart.
Asymmetric Synthesis of (-)-(1R,2S)-Cispentacin and Related cis- and trans-2-Amino Cyclopentane- and Cyclohexane-1-carboxylic Acids
Davies, Stephen G.,Ichihara, Osamu,Lenoir, Isabelle,Walters, Iain A. S.
, p. 1411 - 1416 (2007/10/02)
The antifungal antibiotic (-)-(1R,2S)-2-aminocyclopentane-1-carboxylic acid (cispentacin) 8 and its cyclohexane homologue 14 have been prepared utilizing the highly stereoselective conjugate addition of homochiral lithium N-benzyl-N-α-methylbenzylamide 5.
