Technology Process of methyl (2S,3S,4E)-1-[4-(methylphenyl)sulfonyl]-3-(2-hydroxyethyl)-4-(1-iodoethylidene)-2-pyrrolidinecarboxylate
There total 11 articles about methyl (2S,3S,4E)-1-[4-(methylphenyl)sulfonyl]-3-(2-hydroxyethyl)-4-(1-iodoethylidene)-2-pyrrolidinecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen fluoride; water;
In
acetonitrile;
Inert atmosphere;
DOI:10.1021/ja9063475
- Guidance literature:
-
Multi-step reaction with 7 steps
1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / -1 - 1 °C / Inert atmosphere
2: dihydrogen peroxide / tetrahydrofuran; water / 16.5 h / 20 °C
3: (acetylacetonato)dicarbonylrhodium (l) / toluene / 13 h / 120 °C / 25858.1 Torr / Autoclave
4: methanol; sodium tetrahydroborate / 2 - 5 °C / Inert atmosphere
5: 1H-imidazole / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere
6: Iodine monochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere
7: hydrogen fluoride; water / acetonitrile / 20 °C / Inert atmosphere
With
1H-imidazole; methanol; (acetylacetonato)dicarbonylrhodium (l); sodium tetrahydroborate; hydrogen fluoride; water; dihydrogen peroxide; Iodine monochloride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
1: Mitsunobu reaction;
DOI:10.1021/jo101790z
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium tetrahydroborate / ethanol / 8 - 21 °C / Inert atmosphere
2: triphenylphosphine; diethylazodicarboxylate / dichloromethane / -1 - 1 °C / Inert atmosphere
3: dihydrogen peroxide / tetrahydrofuran; water / 16.5 h / 20 °C
4: (acetylacetonato)dicarbonylrhodium (l) / toluene / 13 h / 120 °C / 25858.1 Torr / Autoclave
5: methanol; sodium tetrahydroborate / 2 - 5 °C / Inert atmosphere
6: 1H-imidazole / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere
7: Iodine monochloride / dichloromethane / 2 h / 20 °C / Inert atmosphere
8: hydrogen fluoride; water / acetonitrile / 20 °C / Inert atmosphere
With
1H-imidazole; methanol; (acetylacetonato)dicarbonylrhodium (l); sodium tetrahydroborate; hydrogen fluoride; water; dihydrogen peroxide; Iodine monochloride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
2: Mitsunobu reaction;
DOI:10.1021/jo101790z
