methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

Base Information

Chemical Name:methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate
CAS No.:1190409-87-0
Molecular Formula:C₂₂H₂₅NO₄SSe
Molecular Weight:478.471
Hs Code.:

Synonyms:methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

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Technology Process of methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

There total 5 articles about methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 960004-39-1
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-4-(phenylseleno)butanoate

: 764-01-2
methyl propargyl alcohol

: 1190409-87-0
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere; Cooling with ice;
DOI:10.1021/ja9063475

Reference yield:

: 1190409-86-9
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-4-iodo-butanoate

: 1190409-87-0
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 8 - 21 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / dichloromethane / -1 - 1 °C / Inert atmosphere

With sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/jo101790z

Reference yield:

: C₁₁H₁₄INO₄S

: 1190409-87-0
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 8 - 21 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / dichloromethane / -1 - 1 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/jo101790z