4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde

Base Information

• Chemical Name: 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde
• CAS No.: 439148-93-3
• Molecular Formula: C₁₅H₁₁FN₄OS
• Molecular Weight: 314.343
• Mol file: 439148-93-3.mol

Synonyms:4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde

Chemical Property of 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde

There total 5 articles about 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

dimethoxyacetaldehyde (51673-84-8) + 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil (218162-50-6) → 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde (439148-93-3)

Guidance literature:

With ammonium acetate; acetic acid; In various solvent(s); at 20 ℃;

DOI:10.1016/S0960-894X(01)00034-8

Reference yield:

2-methylthio-4-methylpyrimidine (14001-63-9) → 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde (439148-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / HMDSNa / tetrahydrofuran / 20 °C

2: 86 percent / aq. HBr; DMSO / 65 °C

3: 80 percent / NH₄OAc; AcOH / various solvent(s) / 20 °C

With ammonium acetate; hydrogen bromide; sodium hexamethyldisilazane; acetic acid; dimethyl sulfoxide; In tetrahydrofuran;

DOI:10.1016/S0960-894X(01)00034-8

Reference yield:

4-fluorobenzoic acid ethyl ester (451-46-7) → 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde (439148-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / HMDSNa / tetrahydrofuran / 20 °C

2: 86 percent / aq. HBr; DMSO / 65 °C

3: 80 percent / NH₄OAc; AcOH / various solvent(s) / 20 °C

With ammonium acetate; hydrogen bromide; sodium hexamethyldisilazane; acetic acid; dimethyl sulfoxide; In tetrahydrofuran;

DOI:10.1016/S0960-894X(01)00034-8

upstream raw materials:

dimethoxyacetaldehyde

2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil

2-methylthio-4-methylpyrimidine

4-fluorobenzoic acid ethyl ester