ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

Base Information

Chemical Name:ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate
CAS No.:136304-61-5
Molecular Formula:C₂₉H₂₉N₃O₂
Molecular Weight:451.568
Hs Code.:

Synonyms:ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

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Chemical Property of ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

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Technology Process of ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

There total 10 articles about ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 64-17-5
ethanol

: 136304-60-4
2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-(cyanomethyl)-1H-benzimidazole

: 136304-61-5
ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

Guidance literature:: With hydrogenchloride; for 2.5h; Heating;
DOI:10.1021/jm00064a011

Reference yield:

: 136304-94-4
methyl 2-(valerylamino)benzoate

: 136304-61-5
ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 28 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature

2: 78 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

3: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating

4: 93 percent / NaBH₄, / methanol; tetrahydrofuran / 27 h / Heating

5: 92 percent / SO₂Cl, DMF / CHCl₃ / 1 h / Heating

6: 94 percent / dimethylformamide / 22 h / Ambient temperature

7: 100 percent / HCl / 2.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; sulfuric acid; nitric acid; acetic anhydride; iron; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011

Reference yield:

: 638-29-9
n-valeryl chloride

: 136304-61-5
ethyl <2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-1H-benzimidazol-7-yl>acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / triethylamine / CHCl₃ / 4 h / 0 °C

2: 28 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature

3: 78 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

4: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating

5: 93 percent / NaBH₄, / methanol; tetrahydrofuran / 27 h / Heating

6: 92 percent / SO₂Cl, DMF / CHCl₃ / 1 h / Heating

7: 94 percent / dimethylformamide / 22 h / Ambient temperature

8: 100 percent / HCl / 2.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; sulfuric acid; nitric acid; acetic anhydride; iron; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011