(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

Base Information

Chemical Name:(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole
CAS No.:197067-75-7
Molecular Formula:C₂₈H₂₉N₅O₄
Molecular Weight:499.569
Hs Code.:

Synonyms:(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

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Chemical Property of (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

Chemical Property:

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Technology Process of (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

There total 1 articles about (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3'S)-Benzyl 2-[4-phenyl-3-(benzyloxycarbonylamino)butanoylamino]propanoate

: 197067-75-7
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

Guidance literature:: With tris-(2-chloro-ethyl)-amine; phosphorus pentachloride; Yield given. Multistep reaction; 1.) benzene, r.t., 90 min, 2.) r.t., 2 d;
DOI:10.1039/a702458d

Reference yield: 84.0%

: 197067-75-7
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

: (S)-2-[5-((S)-2-Amino-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester; hydrobromide

Guidance literature:: With hydrogen bromide; In acetic acid; for 0.333333h; Ambient temperature;
DOI:10.1039/a702458d

Reference yield:

: 197067-75-7
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

: 197067-78-0
(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / 50percent HBr / acetic acid / 0.33 h / Ambient temperature

2: 60 percent / Et₃N, BOP / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

3: 79 percent / AcOH, H₂ / 10percent Pd/C / ethanol / 18 h / Ambient temperature

With hydrogen bromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/a702458d