(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Base Information

Chemical Name:(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole
CAS No.:197067-77-9
Molecular Formula:C₃₄H₃₄N₈O₅
Molecular Weight:634.695
Hs Code.:

Synonyms:(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

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Chemical Property of (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

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Technology Process of (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

There total 2 articles about (1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 136465-98-0
(2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid

: (S)-2-[5-((S)-2-Amino-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid benzyl ester; hydrobromide

: 197067-77-9
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1039/a702458d

Reference yield:

: 197067-75-7
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

: 197067-77-9
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 50percent HBr / acetic acid / 0.33 h / Ambient temperature

2: 60 percent / Et₃N, BOP / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

With hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/a702458d

Reference yield: 79.0%

: 197067-77-9
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

: 197067-78-0
(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 18h; Ambient temperature;
DOI:10.1039/a702458d