(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

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Chemical Name:(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid
CAS No.:197067-78-0
Molecular Formula:C₂₇H₂₈N₈O₅
Molecular Weight:544.57
Hs Code.:

Synonyms:(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

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Chemical Property of (S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

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Technology Process of (S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

There total 4 articles about (S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 197067-77-9
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[3''-phenyl-2''-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

: 197067-78-0
(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 18h; Ambient temperature;
DOI:10.1039/a702458d

Reference yield:

: 136465-98-0
(2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid

: 197067-78-0
(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Et₃N, BOP / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

2: 79 percent / AcOH, H₂ / 10percent Pd/C / ethanol / 18 h / Ambient temperature

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a702458d

Reference yield:

: 197067-75-7
(1'S,2''S)-[1'-(Benzyloxycarbonyl)ethyl]-5-[2''-(benzyloxycarbonylamino)-3''-phenylpropyl]-1H-tetrazole

: 197067-78-0
(S)-2-[5-((S)-2-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-3-phenyl-propyl)-tetrazol-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / 50percent HBr / acetic acid / 0.33 h / Ambient temperature

2: 60 percent / Et₃N, BOP / CH₂Cl₂; dimethylformamide / 1 h / Ambient temperature

3: 79 percent / AcOH, H₂ / 10percent Pd/C / ethanol / 18 h / Ambient temperature

With hydrogen bromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/a702458d