4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

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Chemical Name:4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol
CAS No.:1376514-63-4
Molecular Formula:C₂₅H₄₂N₄O₃Si
Molecular Weight:474.719
Hs Code.:

Synonyms:4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

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Chemical Property of 4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

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Technology Process of 4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

There total 7 articles about 4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-61-2
5-[4-(benzyloxy)-2-methoxybenzyl]-N₄-[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]-6-methylpyrimidine-2,4-diamine

: 1376514-63-4
4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 2250.23 Torr;

Reference yield:

: 1376514-59-8
(3S)-3-({2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)-hexan-1-ol

: 1376514-63-4
4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 27 h / Inert atmosphere

2: hydrogen / palladium on activated charcoal / ethanol / 4 h / 2250.23 Torr

With 1H-imidazole; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 171768-67-5
4-benzyloxy-1-bromo-2-methoxybenzene

: 1376514-63-4
4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutyl-ammonium chloride; N-Methyldicyclohexylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

2: methanol / 5 h / 60 °C

3: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 3 h / 50 °C

4: trifluoroacetic acid / propyl cyanide / 20 h / 120 °C

5: 1H-imidazole / N,N-dimethyl-formamide / 27 h / Inert atmosphere

6: hydrogen / palladium on activated charcoal / ethanol / 4 h / 2250.23 Torr

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; N-Methyldicyclohexylamine; tetrabutyl-ammonium chloride; hydrogen; trifluoroacetic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); palladium on activated charcoal; In tetrahydrofuran; methanol; propyl cyanide; ethanol; N,N-dimethyl-formamide; 1: Heck Reaction;