(3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Base Information

Chemical Name:(3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol
CAS No.:1376514-65-6
Molecular Formula:C₂₃H₃₇N₅O₃
Molecular Weight:431.578
Hs Code.:

Synonyms:(3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

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Chemical Property of (3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

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Technology Process of (3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

There total 7 articles about (3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 1376514-63-4
4-[(2-amino-4-{[(3S)-1-{[tert-butyl(dimethyl)silyl]oxy}hexan-3-yl]amino}-6-methyl-pyrimidin-5-yl)methyl]-3-methoxyphenol

: 1376514-65-6
(3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 60 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1376514-59-8
(3S)-3-({2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl}amino)-hexan-1-ol

: 1376514-65-6
(3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 27 h / Inert atmosphere

2: hydrogen / palladium on activated charcoal / ethanol / 4 h / 2250.23 Torr

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 60 °C / Inert atmosphere

With 1H-imidazole; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 171768-67-5
4-benzyloxy-1-bromo-2-methoxybenzene

: 1376514-65-6
(3S)-3-[(2-amino-5-{4-[2-(dimethylamino)ethoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: tetrabutyl-ammonium chloride; N-Methyldicyclohexylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

2: methanol / 5 h / 60 °C

3: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 3 h / 50 °C

4: trifluoroacetic acid / propyl cyanide / 20 h / 120 °C

5: 1H-imidazole / N,N-dimethyl-formamide / 27 h / Inert atmosphere

6: hydrogen / palladium on activated charcoal / ethanol / 4 h / 2250.23 Torr

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 60 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; di-isopropyl azodicarboxylate; N-Methyldicyclohexylamine; tetrabutyl-ammonium chloride; hydrogen; triphenylphosphine; trifluoroacetic acid; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); palladium on activated charcoal; In tetrahydrofuran; methanol; propyl cyanide; ethanol; N,N-dimethyl-formamide; 1: Heck Reaction;