2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Base Information

Chemical Name:2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate
CAS No.:1376514-57-6
Molecular Formula:C₃₅H₄₃N₃O₅S
Molecular Weight:617.81
Hs Code.:

Synonyms:2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

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Chemical Property of 2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

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Technology Process of 2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

There total 3 articles about 2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 1376514-55-4
2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-ol

: 1376514-57-6
2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: 2,4,6-triisopropylphenylsulfonyl chloride; 2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-ol; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 50 ℃; for 3h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 171768-67-5
4-benzyloxy-1-bromo-2-methoxybenzene

: 1376514-57-6
2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl-ammonium chloride; N-Methyldicyclohexylamine / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

2: methanol / 5 h / 60 °C

3: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 3 h / 50 °C

With 1,4-diaza-bicyclo[2.2.2]octane; N-Methyldicyclohexylamine; tetrabutyl-ammonium chloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Heck Reaction;

Reference yield:

: 1376514-53-2
methyl 2-[4-(benzyloxy)-2-methoxybenzyl]-3-oxobutanoate

: 1376514-57-6
2-amino-5-[4-(benzyloxy)-2-methoxybenzyl]-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 5 h / 60 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 3 h / 50 °C

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; methanol;