(S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

Base Information

Chemical Name:(S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol
CAS No.:1398243-28-1
Molecular Formula:C₂₀H₃₄O₄Si
Molecular Weight:366.573
Hs Code.:

Synonyms:(S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

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Chemical Property of (S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

Chemical Property:

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Technology Process of (S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

There total 6 articles about (S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1398244-40-0
(S)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-yn-3-ol

: 1398243-28-1
(S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

Guidance literature:: With quinoline; hydrogen; In ethyl acetate; at 50 ℃; for 1h;
DOI:10.1021/jo3016055

Reference yield:

: 4925-88-6
2,5-dimethoxy-4-methylbenzaldehyde

: 1398243-28-1
(S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -10 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere

3.1: hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium hexacyanoferrate(III); potassium carbonate; potassium dioxido(dioxo)osmium hydrate; methanesulfonamide / water; tert-butyl alcohol / 19 h / 0 °C

4.1: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

6.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.2: 0.17 h / -78 °C / Inert atmosphere

6.3: 1 h / -78 °C / Inert atmosphere

7.1: quinoline; hydrogen / ethyl acetate / 1 h / 50 °C

With quinoline; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; methanesulfonamide; potassium dioxido(dioxo)osmium hydrate; potassium hexacyanoferrate(III); hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo3016055

Reference yield:

: 1398245-40-3
(S)-3-(2,5-dimethoxy-4-methylphenoxy)-3-methylbutane-1,2-diol

: 1398243-28-1
(S,Z)-2-(2,5-dimethoxy-4-methylphenoxy)-2-methyl-7-(trimethylsilyl)hept-5-en-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

3.3: 1 h / -78 °C / Inert atmosphere

4.1: quinoline; hydrogen / ethyl acetate / 1 h / 50 °C

With quinoline; dmap; n-butyllithium; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate;
DOI:10.1021/jo3016055