Technology Process of (S)-3-(2,5-dimethoxy-4-methylphenoxy)-3-methylbutane-1,2-diol
There total 5 articles about (S)-3-(2,5-dimethoxy-4-methylphenoxy)-3-methylbutane-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; methanesulfonamide; potassium osmate monohydrate; potassium hexacyanoferrate(III); potassium carbonate;
In
water; tert-butyl alcohol;
at 0 ℃;
for 19h;
Overall yield = 92 %; Overall yield = 6.43 g;
DOI:10.1021/jo3016055
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -10 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere
3.1: hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium hexacyanoferrate(III); potassium carbonate; potassium dioxido(dioxo)osmium hydrate; methanesulfonamide / water; tert-butyl alcohol / 19 h / 0 °C
With
tetrakis(triphenylphosphine) palladium(0); hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; methanesulfonamide; potassium dioxido(dioxo)osmium hydrate; potassium hexacyanoferrate(III); sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo3016055
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 0.83 h / 20 °C / Inert atmosphere
1.2: 1 h / 70 °C / Inert atmosphere
2.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -10 °C / Inert atmosphere
2.2: 0.5 h / 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 3.5 h / 20 °C / Inert atmosphere
4.1: hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium hexacyanoferrate(III); potassium carbonate; potassium dioxido(dioxo)osmium hydrate; methanesulfonamide / water; tert-butyl alcohol / 19 h / 0 °C
With
tetrakis(triphenylphosphine) palladium(0); hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; methanesulfonamide; potassium dioxido(dioxo)osmium hydrate; potassium hexacyanoferrate(III); sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo3016055
