tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate
CAS No.:1027385-32-5
Molecular Formula:C₂₅H₂₉F₂N₅O₃
Molecular Weight:485.534
Hs Code.:

Synonyms:tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

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Chemical Property of tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

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Technology Process of tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

There total 2 articles about tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951127-25-6
N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester

: 1027385-18-7
2-methyl-8,9-dihydro-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidine

: tert-butyl [(2R,3S,5S)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

: 1027385-32-5
tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Guidance literature:: N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester; 2-methyl-8,9-dihydro-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidine; In methanol; for 0.5h;

With decaborane; In methanol; for 48h;

Reference yield:

: 1027385-17-6
tert-butyl 2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidine-8(9H)-carboxylate

: tert-butyl [(2R,3S,5S)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

: 1027385-32-5
tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h

2: nido-decaborane / methanol / 16 h

With hydrogenchloride; nido-decaborane; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2016.04.020

Reference yield:

: 1027385-32-5
tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

: 76-05-1
trifluoroacetic acid

: (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-amine bis-trifluoroacetic acid salt

Guidance literature:: tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methyl-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate; With hydrogenchloride; In 1,4-dioxane; for 0.5h;

trifluoroacetic acid; In water; acetonitrile;