951127-25-6Relevant articles and documents
Stereoselective and Regioselective Preparation of C-Pentopyranosides and Formal Synthesis of Omarigliptin
Liu, Tongchao,Hou, Jian,Xie, Wuchen,Li, You,Ren, Huanming,Liang, Jianpeng,Xiong, Bing,Chen, Guohua,Cheng, Maosheng,Zhao, Dongmei,Shen, Jingkang,Chen, Yue-Lei
, p. 5624 - 5628 (2016)
A readily available intermediate obtained from d-arabinose was identified as a versatile starting material for the stereoselective synthesis of C-pentopyranosides in one pot. For two of the C-pentopyranosides, subsequent epoxide ring formation and a regioselective opening process was proven to be a robust approach to 3-deoxy C-pentopyranosides in two to four steps. A key intermediate used in the preparation of omarigliptin was obtained in four steps. Most of the conversions were high-yielding and proceeded with high selectivities on a multigram scale.
Chiral tetrahydropyrane derivatives as well as preparation and application thereof
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, (2018/03/25)
The invention discloses compounds. The compounds are represented by a formula 22 in the description, wherein R is one selected from the group consisting of 5 to 6-membered aryl substituted with one ormore of halogen, C1-C3 alkyl, and C2-C3 alkenyl, 5 to 6-membered heteroaryl containing 1-2 sulfur atoms, C1-C3 alkyl substituted by C1-C3 alkylthio, and 5 to 6-membered cycloalkyl containing 1-2 sulfur atoms. The invention also discloses a preparation method and application of the compounds. The method provided by the invention can realize synthesis of a plurality of the novel tetrahydropyrane chiral derivatives without involving raw materials such as noble metal catalysts, and the costs are reduced.
Amino tetrahydropyrane derivatives
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, (2017/08/28)
The invention provides amino tetrahydropyrane derivatives, pharmaceutically-acceptable salts, hydrates, solvates, stereoisomers and prodrugs of the amino tetrahydropyrane derivatives, a preparation method of the amino tetrahydropyrane derivatives and a pharmaceutical composition containing the compounds. A formula (I) of the amino tetrahydropyrane derivatives is as shown in the specification. The compounds are capable of inhibiting activity of DPP-IV (dipeptidyl peptidase IV) and can be used for treating dipeptidyl peptidase IV associated diseases such as diabetes, obesity and other metabolic diseases.
