4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

Base Information

Chemical Name:4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid
CAS No.:240429-12-3
Molecular Formula:C₂₄H₄₃N₃O₇
Molecular Weight:485.621
Hs Code.:

4-[(2,6-bis-<i>tert</i>-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

Synonyms:4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

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Chemical Property of 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

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Technology Process of 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

There total 1 articles about 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid

: 2483-46-7
Boc-Lys(Boc)-OH

: 240429-12-3
4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 4 ℃; for 12h;
DOI:10.1016/S0960-894X(99)00226-7

Reference yield:

: 240429-12-3
4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

: [5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethylene}-amino)-propyl]-piperazin-1-yl}-propylimino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) cyanuric fluoride, pyridine, 2.) NaBH₄, MeOH / 1.) CH₂Cl₂, 0 deg C, 2 h, 2.) CH₂Cl₂, RT, 5 h

2: 95 percent / PCC, SiO₂ / CH₂Cl₂ / 5 h / Ambient temperature

3: molecular sieves / 12 h / Ambient temperature

With pyridine; methanol; sodium tetrahydroborate; trifluoro-[1,3,5]triazine; molecular sieve; silica gel; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/S0960-894X(99)00226-7

Reference yield:

: 240429-12-3
4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid

: 240429-15-6
[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) cyanuric fluoride, pyridine, 2.) NaBH₄, MeOH / 1.) CH₂Cl₂, 0 deg C, 2 h, 2.) CH₂Cl₂, RT, 5 h

2: 95 percent / PCC, SiO₂ / CH₂Cl₂ / 5 h / Ambient temperature

3: molecular sieves / 12 h / Ambient temperature

4: NaBH₄ / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; methanol; sodium tetrahydroborate; trifluoro-[1,3,5]triazine; molecular sieve; silica gel; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/S0960-894X(99)00226-7