N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

Base Information

Chemical Name:N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride
CAS No.:881680-86-0
Molecular Formula:C₁₈H₁₇N₃O₄S*ClH
Molecular Weight:407.878
Hs Code.:

Synonyms:N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

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Chemical Property of N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

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Technology Process of N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

There total 7 articles about N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 881676-87-5
1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

: 74-89-5
methylamine

: 881680-86-0
N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

Guidance literature:: 1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde; methylamine; In methanol; at 10 - 35 ℃; for 0.5h;

With methanol; sodium tetrahydroborate; at 10 - 35 ℃; for 0.166667h;

With hydrogenchloride; In methanol; ethyl acetate;

Reference yield:

: hydrogen chloride-ethyl acetate

: 881676-87-5
1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

: 52682-00-5
methylamine methanol

: 881680-86-0
N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

Guidance literature:: With hydrogenchloride; sodium borohydrid; In methanol;

Reference yield:

: 158692-57-0
Ethyl 2-chloro-5-phenyl-1H-pyrrole-3-carboxylate

: 881680-86-0
N-methyl-1-{1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}methanamine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 10 - 35 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.17 h / -78 °C

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1.5 h / 10 - 35 °C / Molecular sieve

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 10 - 35 °C

4.2: 0.5 h

4.3: 1 h

5.1: methanol / 0.5 h / 10 - 35 °C

5.2: 0.17 h / 10 - 35 °C

With tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; toluene; acetonitrile; mineral oil;