4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Base Information

Chemical Name:4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid
CAS No.:153693-42-6
Molecular Formula:C₂₄H₃₃IO₁₁
Molecular Weight:624.424
Hs Code.:

Synonyms:4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Suppliers and Price of 4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

There total 13 articles about 4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 153693-57-3
2,2-Dimethyl-propionic acid (2S,3R,4R,5S,6S)-5-acetoxy-2-(4-hydroxymethyl-2-iodo-5,6-dimethoxy-3-methyl-phenoxy)-4-methoxy-6-methyl-tetrahydro-pyran-3-yl ester

: 153693-42-6
4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; 1.) 0 deg C, 1 h, 2.) 25 deg C, 1.5 h;
DOI:10.1021/ja00084a018

Reference yield:

: 115592-74-0,115650-45-8,127761-05-1
4-Hydroxy-5-iod-2,3-dimethoxy-6-methyl-benzoesaeuremethylester

: 153693-42-6
4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL / CH₂Cl₂ / 1.) -78 deg C, 10 min, 2.) 25 deg C, 5 min

2: imidazole / dimethylformamide / 2 h / 65 °C

3: 1.) 2,6-di-tert-butyl-4-methylpyridine, 2.) (Bu₃Sn)2O

4: 84 percent / TBAF / tetrahydrofuran / 4 h / 25 °C

5: 79 percent / NaIO₄, RuCl₃ / CCl₄; acetonitrile; H₂O / 1.) 0 deg C, 1 h, 2.) 25 deg C, 1.5 h

With 1H-imidazole; ruthenium trichloride; sodium periodate; 2,6-di-tert-butyl-4-methylpyridine; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; bis(tri-n-butyltin)oxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00084a018

Reference yield:

: 3282-30-2
pivaloyl chloride

: 153693-42-6
4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine / 6 h / 60 °C

2: 92 percent / mCPBA / CH₂Cl₂ / 0.83 h / -78 - 0 °C

3: 1.) 2,6-di-tert-butyl-4-methylpyridine, 2.) (Bu₃Sn)2O

4: 84 percent / TBAF / tetrahydrofuran / 4 h / 25 °C

5: 79 percent / NaIO₄, RuCl₃ / CCl₄; acetonitrile; H₂O / 1.) 0 deg C, 1 h, 2.) 25 deg C, 1.5 h

With pyridine; ruthenium trichloride; sodium periodate; 2,6-di-tert-butyl-4-methylpyridine; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; bis(tri-n-butyltin)oxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ja00084a018