(R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester

Base Information

• Chemical Name: (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester
• CAS No.: 76918-59-7
• Molecular Formula: C₁₆H₁₇F₃O₇
• Molecular Weight: 378.302
• Mol file: 76918-59-7.mol

Synonyms:(R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester

Chemical Property of (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester

There total 6 articles about (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-dimethyl malate (70681-41-3) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester (76918-59-7)

Guidance literature:

With pyridine;

DOI:10.1016/j.tet.2015.05.112

Reference yield:

methanol (67-56-1) + sarglabolide K + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C16H17F3O5 + (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester (76918-59-7)

Guidance literature:

sarglabolide K; With water; potassium carbonate; In methanol; at 60 ℃; for 2h;

methanol; With thionyl chloride; at 20 ℃; for 12h;

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride; With pyridine;

DOI:10.1016/j.tet.2015.05.112

Reference yield:

methanol (67-56-1) + sarglabolide A + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C16H17F3O5 + (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester (76918-59-7)

Guidance literature:

sarglabolide A; With water; potassium carbonate; In methanol; at 60 ℃; for 2h;

methanol; With thionyl chloride; at 20 ℃; for 12h;

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride; With pyridine;

DOI:10.1016/j.tet.2015.05.112

upstream raw materials:

methanol

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-dimethyl malate