(E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

Base Information

Chemical Name:(E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide
CAS No.:1356930-00-1
Molecular Formula:C₁₂H₁₄BrN₃O₅
Molecular Weight:360.164
Hs Code.:

Synonyms:(E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

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Technology Process of (E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

There total 10 articles about (E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

: 1095208-30-2
psammaplin M

: 1356930-00-1
(E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

Guidance literature:: With hydroxylamine monohydrate; sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/acsmedchemlett.0c00369

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 1356930-00-1
(E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate / Reflux

2: hydrogenchloride; water / Reflux

3: pyridine / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 3 h / 20 °C

5: triethylamine / 1,4-dioxane / 20 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 20 h / 20 °C

With pyridine; hydrogenchloride; water; sodium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1021/jm2016182

Reference yield:

: 390424-25-6
3-(3-bromo-4-hydroxyphenyl)-2-oxopropionic acid

: 1356930-00-1
(E)‐3‐(3‐bromo‐4‐hydroxyphenyl)‐N‐(3‐(hydroxyamino)‐3‐oxopropyl)‐2‐(hydroxyimino)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 3 h / 20 °C

3: triethylamine / 1,4-dioxane / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 20 h / 20 °C

With pyridine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1021/jm2016182