t-butyl 2-hydroxy-3-phenoxypropioate

Base Information

• Chemical Name: t-butyl 2-hydroxy-3-phenoxypropioate
• CAS No.: 872526-09-5
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• Mol file: 872526-09-5.mol

Synonyms:t-butyl 2-hydroxy-3-phenoxypropioate

Chemical Property of t-butyl 2-hydroxy-3-phenoxypropioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 2-hydroxy-3-phenoxypropioate

There total 1 articles about t-butyl 2-hydroxy-3-phenoxypropioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

tert-butyl cis-2,3-dihydroxypropanoate (235090-36-5) + phenol (108-95-2,27073-41-2) → t-butyl 2-hydroxy-3-phenoxypropioate (872526-09-5)

Guidance literature:

With sodium hydride; In various solvent(s); at 45 ℃; for 43h;

DOI:10.3987/COM-05-10504

Reference yield: 85.0%

t-butyl 2-hydroxy-3-phenoxypropioate (872526-09-5) → t-butyl phenoxypyruvate (872526-15-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;

DOI:10.3987/COM-05-10504

Reference yield:

t-butyl 2-hydroxy-3-phenoxypropioate (872526-09-5) → t-butyl 4-(t-butoxycarbonyl)-3,5-diphenoxy-4-hydroxy-2-oxopentanoate

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

2: 85 percent / TMSC(Li)N₂; TMEDA / diethyl ether; hexane / 2 h / Heating

With N,N,N,N,-tetramethylethylenediamine; TMSC(Li)N₂; Dess-Martin periodane; In diethyl ether; hexane; dichloromethane;

DOI:10.3987/COM-05-10504

upstream raw materials:

tert-butyl cis-2,3-dihydroxypropanoate

phenol

Downstream raw materials:

t-butyl phenoxypyruvate