5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole
• CAS No.: 1449036-28-5
• Molecular Formula: C₂₄H₁₇Cl₃N₄O₂
• Molecular Weight: 499.784
• Mol file: 1449036-28-5.mol

Synonyms:5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole

Chemical Property of 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole

There total 3 articles about 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N'-(4-(3,5,6-trichloropyridin-2-yloxy)benzylidene)-4-(1Hindol-3-yl)butanehydrazide (1449036-06-9) → 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole (1449036-28-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2013.05.024

Reference yield:

ethyl 4-(1H-indol-3-yl) butanoate (49850-32-0) → 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole (1449036-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / water; ethanol / 5 h / Reflux

2: ethanol / Reflux

3: [bis(acetoxy)iodo]benzene / dichloromethane / 20 °C

With [bis(acetoxy)iodo]benzene; hydrazine hydrate; In ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.05.024

Reference yield:

4-indol-3-yl-butyric acid (133-32-4) → 5-(3-(1H-indol-3-yl)propyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy)phenyl)-1,3,4-oxadiazole (1449036-28-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 3 h / Reflux

2: hydrazine hydrate / water; ethanol / 5 h / Reflux

3: ethanol / Reflux

4: [bis(acetoxy)iodo]benzene / dichloromethane / 20 °C

With [bis(acetoxy)iodo]benzene; sulfuric acid; hydrazine hydrate; In ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.05.024

upstream raw materials:

N'-(4-(3,5,6-trichloropyridin-2-yloxy)benzylidene)-4-(1Hindol-3-yl)butanehydrazide

ethyl 4-(1H-indol-3-yl) butanoate

4-indol-3-yl-butyric acid