2-Chloro-5-Methylpyridine zinc broMide

Base Information

• Chemical Name: 2-Chloro-5-Methylpyridine zinc broMide
• CAS No.: 775335-61-0
• Molecular Formula: C₆H₅BrClNZn
• Molecular Weight: 271.859
• Mol file: 775335-61-0.mol

Synonyms:(2-chloro-pyrid-5-yl)methylzinc chloride

Chemical Property of 2-Chloro-5-Methylpyridine zinc broMide

Chemical Property:

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Technology Process of 2-Chloro-5-Methylpyridine zinc broMide

There total 1 articles about 2-Chloro-5-Methylpyridine zinc broMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(bromomethyl)-2-chloropyridine (182924-36-3) → (2-chloro-pyrid-5-yl)methylzinc chloride (775335-61-0)

Guidance literature:

With chloro-trimethyl-silane; iodine; ethylene dibromide; lithium chloride; zinc; In tetrahydrofuran; at 25 ℃; for 3h;

DOI:10.1080/00397911.2019.1663540

Reference yield:

3-chloro-5-(trifluoromethyl)benzyl bromide (886496-91-9) + N-phenyl-1-(2-vinylphenyl)methanimine (852546-91-9) + (2-chloro-pyrid-5-yl)methylzinc chloride (775335-61-0) → C29H23Cl2F3N2

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 3h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.0c09778 DOI:10.1021/jacs.1c06574

Reference yield:

(2-chloro-pyrid-5-yl)methylzinc chloride (775335-61-0) + 1-(5-fluoro-2-vinylphenyl)-N-phenylmethanimine + benzyl bromide (100-39-0) → C28H24ClFN2

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 3h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.0c09778 DOI:10.1021/jacs.1c06574

upstream raw materials:

5-(bromomethyl)-2-chloropyridine