Scopolamine hydrobromide

Base Information

• Chemical Name: Scopolamine hydrobromide
• CAS No.: 114-49-8
• Molecular Formula: C17H21NO4.HBr
• Molecular Weight: 384.27
• Hs Code.: 2939800000
• European Community (EC) Number: 204-050-6
• Mol file: 114-49-8.mol

Synonyms:1aH,5aH-Tropan-3a-ol, 6b,7b-epoxy-, (-)-tropate (ester), hydrobromide (8CI);Benzeneacetic acid, a-(hydroxymethyl)-, (1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobromide, (aS)- (9CI);Benzeneacetic acid, a-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobromide, [7(S)-(1a,2b,4b,5a,7b)]-;Scopolamine bromide (6CI);(-)-Hyoscinehydrobromide;(-)-Scopolamine bromide;(-)-Scopolamine hydrobromide;Beldavrin;Euscopol;Hydroscine hydrobromide;Hyocine F hydrobromide;Hyoscine bromide;Hyoscine hydrobromide;Hysco;Isoscopil;Kwells;Scopamin;Scopolaminehydrobromide;Scopolaminium bromide;Scopolammonium bromide;Scopos;Sea Legs;Sereen;Triptone;Wellcome Brand Scopolamine hydrobromide Injection;l-Hyoscinehydrobromide;l-Scopolamine hydrobromide;

Chemical Property of Scopolamine hydrobromide

Chemical Property:

• Appearance/Colour: white crystalline solid powder
• Vapor Pressure: 2.51E-10mmHg at 25°C
• Melting Point: 195-199 °C (dry matter)(lit.)
• Boiling Point: 460.3 °C at 760 mmHg
• Flash Point: 232.2 °C
• PSA: 62.30000
• LogP: 1.81410
• Storage Temp.: Store at RT
• Solubility.: H2O: 50 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 383.07322
• Heavy Atom Count: 23
• Complexity: 418

Purity/Quality:

99% ^*data from raw suppliers

Scopolamine Hydrobromide ≥99%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.Br
• Isomeric SMILES: CN1C2CC(CC1C3C2O3)OC(=O)[C@H](CO)C4=CC=CC=C4.Br
• Recent EU Clinical Trials: A Randomised Double-Blinded Placebo-Controlled Trial to Assess the Efficacy and Safety of Scopolamine Compared to Placebo in Individuals with Bipolar Disorder who are Experiencing a Depressive Episode (SCOPE-BD)
• Description: Scopolamine is a tropane alkaloid that can be found in many plants of the Solanaceae (nightshade) family. It is a muscarinic receptor antagonist that can be used to induce memory impairment in animals. Scopolamine prevents motion sickness, nausea, and vomiting in animals.
• Uses: An acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant
• Clinical Use: A sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.
• Drug interactions: Potentially hazardous interactions with other drugs None known

Technology Process of Scopolamine hydrobromide

There total 2 articles about Scopolamine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ tropenol hydrochloride + hyoscine hydrobromide (114-49-8)

Guidance literature:

Reference yield:

→ (+/-)-scopolamine; hydrobromide (114-49-8,305-67-9,672-21-9,20368-51-8,53448-17-2)

Guidance literature:

With water;

Reference yield: 95.0%

hyoscine hydrobromide (114-49-8) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → pyrrolidine-2-carboxylic acid 2-(9-methyl-3-oxa-9-aza-tricyclo[3.3.1.02,4]non-7-yloxycarbonyl)-2-phenyl-ethyl ester

Guidance literature:

at 120 ℃; for 7h;

DOI:10.1007/s11172-006-0562-y

Downstream raw materials:

Norscopolamine

(-)-Formylnorscopollamin

(-)-O-Acetylscopolamin-hydrobromid

9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate

Refernces