4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

Base Information

Chemical Name:4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol
CAS No.:73746-75-5
Molecular Formula:C₁₈H₂₇NO₃
Molecular Weight:305.417
Hs Code.:

Synonyms:4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

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Chemical Property of 4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

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Technology Process of 4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

There total 13 articles about 4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52075-14-6
(4S,5S)-(-)-4,5-dihydro-4-methoxymethyl-2-methyl-5-phenyloxazole

: 73746-75-5
4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1) lithium diisopropylamide / 1) THF / -78 deg C / 1h 2a) -78 deg C / 10h 2b) r.t./ 5h

2: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1h 2) -78 deg C, 6h

3: EtOH/H₂O / 2.5 h / Heating

With ethanol; water; lithium diisopropyl amide;
DOI:10.1021/jo01302a009

Reference yield:

: 73713-17-4
(4S,5S)-2-n-Pentyl-4-(methoxymethyl)-5-phenyl-2-oxazoline

: 73746-75-5
4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C 2) -98 deg C

2: 4.5N HCl / Heating

3: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

4: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

5: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1h 2) -78 deg C, 6h

6: EtOH/H₂O / 2.5 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; ethanol; water; lithium diisopropyl amide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009

Reference yield:

: 2427-16-9
5-hydroxy-pentanenitrile

: 73746-75-5
4-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-heptan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / 3 h / 0 °C

2: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

3: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

4: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1h 2) -78 deg C, 6h

5: EtOH/H₂O / 2.5 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; ethanol; water; lithium diisopropyl amide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009