(4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

Base Information

Chemical Name:(4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole
CAS No.:73746-71-1
Molecular Formula:C₂₁H₃₅NO₃Si
Molecular Weight:377.599
Hs Code.:

Synonyms:(4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

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Chemical Property of (4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

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Technology Process of (4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

There total 12 articles about (4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52075-14-6
(4S,5S)-(-)-4,5-dihydro-4-methoxymethyl-2-methyl-5-phenyloxazole

: 73746-71-1
(4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) THF / -78 deg C / 1h 2a) -78 deg C / 10h 2b) r.t./ 5h

2: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1h 2) -78 deg C, 6h

With lithium diisopropyl amide;
DOI:10.1021/jo01302a009

Reference yield:

: 55232-20-7
(4S,5S)-2-<3-<(Trimethylsilyl)oxy>propyl>-4-(methoxymethyl)-5-phenyl-2-oxazoline

: 73746-71-1
(4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C 2) -98 deg C

2: 4.5N HCl / Heating

3: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

4: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

5: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1h 2) -78 deg C, 6h

With 2,6-dimethylpyridine; hydrogenchloride; lithium diisopropyl amide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009

Reference yield:

: 73713-17-4
(4S,5S)-2-n-Pentyl-4-(methoxymethyl)-5-phenyl-2-oxazoline

: 73746-71-1
(4S,5S)-4-Methoxymethyl-5-phenyl-2-(1-propyl-4-trimethylsilanyloxy-butyl)-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C 2) -98 deg C

2: 4.5N HCl / Heating

3: 1.3 g / CH₂Cl₂ / 3 h / Ambient temperature

4: 2,6-Lutidine / CCl₄ / 1.5 h / Ambient temperature

5: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1h 2) -78 deg C, 6h

With 2,6-dimethylpyridine; hydrogenchloride; lithium diisopropyl amide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jo01302a009