4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

Base Information

Chemical Name:4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester
CAS No.:1100767-77-8
Molecular Formula:C₁₅H₂₀F₃NO₃
Molecular Weight:319.324
Hs Code.:

Synonyms:4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

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Chemical Property of 4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

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Technology Process of 4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

There total 2 articles about 4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1100767-76-7
4-(4-acetyl-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

: 1100767-77-8
4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

Guidance literature:: 4-(4-acetyl-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester; With ammonium acetate; In methanol; at 20 ℃; for 12h;

With sodium cyanoborohydride; In methanol; for 8h; Heating / reflux;

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 1100767-77-8
4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: ammonium acetate / methanol / 12 h / 20 °C

2.2: 8 h / Heating / reflux

With ammonium acetate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield: 33.0%

: 1100767-77-8
4-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-butyric acid ethyl ester

: 1100767-27-8
N-(4-carbamimidoyl-phenyl)-malonamic acid trifluoroacetate

: 1100767-78-9
4-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;