N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal

Base Information

• Chemical Name: N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal
• CAS No.: 101471-18-5
• Molecular Formula: C₁₂H₁₇F₂NO₃
• Molecular Weight: 261.269
• Mol file: 101471-18-5.mol

Synonyms:N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal

Chemical Property of N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal

There total 3 articles about N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,5-Difluoro-4-methoxybenzaldehyde (654-11-5) + 2,2-dimethoxyethylamine (22483-09-6) → N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal (101471-18-5)

Guidance literature:

In ethyl acetate;

Reference yield:

[1-(3,5-Difluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(2,2-dimethoxy-ethyl)-amine (124068-57-1) → N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal (101471-18-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00156a002

Reference yield:

3,5-Difluoro-4-methoxybenzaldehyde (654-11-5) → N-(3,5-difluoro-4-methoxybenzyl)-aminoacetaldehyde dimethyl acetal (101471-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.33 h / Heating

2: sodium borohydride / ethanol / 24 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm00386a008

upstream raw materials:

[1-(3,5-Difluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(2,2-dimethoxy-ethyl)-amine

3,5-Difluoro-4-methoxybenzaldehyde

2,2-dimethoxyethylamine

Downstream raw materials:

1-(4'-methoxy-3',5'-difluorobenzyl)-1,3-dihydro-2H-imidazole-2-thione

1-(4'-hydroxy-3',5'-difluorobenzyl)-1,3-dihydro-2H-imidazole-2-thione

1-(3,5-difluoro-4-methoxybenzyl)-2-mercaptoimidazole