4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Base Information

Chemical Name:4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile
CAS No.:1520089-79-5
Molecular Formula:C₂₂H₂₉NOSi
Molecular Weight:351.564
Hs Code.:

Synonyms:4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Suppliers and Price of 4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

There total 5 articles about 4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 53172-91-1
(benzyloxy)(tert-butyl)dimethylsilane

: 39095-25-5
2,5-dimethylbenzene-1,4-dicarbonitrile

: 1520089-79-5
4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Guidance literature:: With tris[2-phenylpyridinato-C₂,N]iridium(III); dipotassium hydrogenphosphate; Octanal; Methyl thioglycolate; In N,N-dimethyl acetamide; at -78 - 23 ℃; for 12h; Irradiation; Inert atmosphere;
DOI:10.1021/ja411596q

Reference yield:

: 132868-67-8
(tert-butyldimethylsilyl)(phenyl)methanone

: 1520089-79-5
4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane; hexane / 1.17 h / -78 - 0 °C / Inert atmosphere

2: Octanal; cesium acetate; tris[2-phenylpyridinato-C₂,N]iridium(III) / N,N-dimethyl acetamide / 24 h / -78 - 20 °C / Inert atmosphere; Sealed tube; Irradiation

With tris[2-phenylpyridinato-C₂,N]iridium(III); Octanal; cesium acetate; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl acetamide; 2: |Brook Silaketone Rearrangement;
DOI:10.1021/jacs.7b05165

Reference yield:

: 461051-83-2
2-phenyl-2-(tert-butyl dimethylsilyl)-1,3-dithiane

: 1520089-79-5
4-(((tert-butyldimethylsilyl)oxy)(phenyl)methyl)-2,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: mercury dichloride; mercury(II) oxide / methanol; water / 3 h / Inert atmosphere; Reflux

2: diisobutylaluminium hydride / dichloromethane; hexane / 1.17 h / -78 - 0 °C / Inert atmosphere

3: Octanal; cesium acetate; tris[2-phenylpyridinato-C₂,N]iridium(III) / N,N-dimethyl acetamide / 24 h / -78 - 20 °C / Inert atmosphere; Sealed tube; Irradiation

With tris[2-phenylpyridinato-C₂,N]iridium(III); Octanal; cesium acetate; diisobutylaluminium hydride; mercury dichloride; mercury(II) oxide; In methanol; hexane; dichloromethane; N,N-dimethyl acetamide; water; 3: |Brook Silaketone Rearrangement;
DOI:10.1021/jacs.7b05165