methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Base Information

Chemical Name:methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate
CAS No.:956580-04-4
Molecular Formula:C₃₀H₃₅NO₅
Molecular Weight:489.612
Hs Code.:

Synonyms:methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Suppliers and Price of methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

There total 4 articles about methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 43153-20-4
5,5-bis-bromomethyl-2,2-dimethyl-[1,3]dioxane

: 956580-04-4
methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Guidance literature:: 3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

5,5-bis-bromomethyl-2,2-dimethyl-[1,3]dioxane; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield: 50.0%

: 863578-50-1
3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester

: 43153-20-4
5,5-bis-bromomethyl-2,2-dimethyl-[1,3]dioxane

: 956580-04-4
methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Guidance literature:: 3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.333333h;

5,5-bis-bromomethyl-2,2-dimethyl-[1,3]dioxane; In N,N-dimethyl-formamide; mineral oil; at 70 ℃; for 4h;
DOI:10.1021/jm1013105

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 956580-04-4
methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

2.2: 4 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 1.1: Suzuki coupling;
DOI:10.1021/jm1013105