43153-20-4

Usage

Uses

Used in Organic Synthesis:
5,5-BIS(BROMOMETHYL)-2,2-DIMETHYL-1,3-DIOXANE is used as a reagent in organic synthesis for the preparation of polymers and specialty chemicals. Its unique structure and reactivity make it a valuable component in the synthesis of various organic compounds.
Used in the Production of Adhesives:
In the adhesives industry, 5,5-BIS(BROMOMETHYL)-2,2-DIMETHYL-1,3-DIOXANE is used as a crosslinking agent. It enhances the adhesive properties of the final product by forming covalent bonds between polymer chains, thereby improving the strength and durability of the adhesive.
Used in the Production of Coatings:
5,5-BIS(BROMOMETHYL)-2,2-DIMETHYL-1,3-DIOXANE is also utilized in the coatings industry as a crosslinking agent. It contributes to the formation of a robust and stable coating by creating a network of covalent bonds between the polymer chains, which results in improved resistance to wear, weathering, and other environmental factors.
Used in the Production of Resins:
In the resin industry, 5,5-BIS(BROMOMETHYL)-2,2-DIMETHYL-1,3-DIOXANE serves as a crosslinking agent, playing a crucial role in the synthesis of thermosetting resins. Its ability to form covalent bonds between polymer chains results in resins with enhanced mechanical properties and thermal stability.
Safety Precautions:
Due to the limited information on the specific hazards and toxicity of 5,5-BIS(BROMOMETHYL)-2,2-DIMETHYL-1,3-DIOXANE, it is essential to exercise caution when handling 5,5-BIS(BROMOMETHYL)-2,2-DIMETHYL-1,3-DIOXANE. Proper safety measures, including the use of personal protective equipment, should be adopted to minimize potential risks to human health and the environment.

Upstream product

• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 
• 126-84-1 2,2-diethoxypropane 
• 77-76-9 2,2-dimethoxy-propane 
• 115-77-5 Pentaerythritol 
• 67-64-1 acetone 

Downstream Products

• 183606-11-3 3,3-bis[(benzoyloxy)methyl]thietane 
• 183606-12-4 3,3-bis[(benzoyloxy)methyl]thietan-1-oxide 
• 959865-42-0 1-[3,3-bis[(benzoyloxy)methyl]thietan-2-yl]thymine 
• 26096-30-0 N-benzyl-3,3-bis-(hydroxymethyl)-azetidine 
• 1121-96-6 4,4-Bis-hydroxymethyl-[1,2]dithiolan 
• 94710-97-1 Pentaerythrit-dicyclohexylether 
• 1335107-23-7 bis((5-((benzylthio)methyl)-2,2-dimethyl-1,3-dioxan-5-yl)methyl)sulfane 
• 956580-04-4 methyl 140-Cyclohexyl-2,2-dimethylspiro[1,3-dioxane-5,70-indolo[1,2-e][1,5]benzoxazocine]-11-carboxylate 
• 156720-48-8 7,7-dimethyl-6,8-dioxa-2-thiaspiro[3.5]nonane 

Relevant academic research and scientific papers

A new family of water-soluble, third generation antitumor platinum complexes

[1,1-Cyclobutanedicarboxylato(2-)-0,0'](1,3-dioxane-5,5-dimethanamine- ,N')platinum (II), 3a, a third generation, very water-soluble platinum complex, has been synthesized along with several of its analogues. All members of the new family contain a 1,3-dioxane or 1,3-dioxolane-1,3-diamine as their basic ligand, a moiety which contributes to their increased water solubility, and a bidentate acid ligand, which is responsible for their good stability. They were all easily crystallized and characterized by 1H NMR and elemental analysis, and the parent complex 3a was further characterized by 13C NMR. Their very desirable physical properties combined with their broad spectrum of antitumor activity and reduced toxicity make them good candidates in further development.

ERK INHIBITOR AND USE THEREOF

Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.

Diverse ring opening of thietanes and other cyclic sulfides: An electrophilic aryne activation approach

Organosulfides are a common class of structure units in bioactive molecules and functional materials motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of one or two

METHOD FOR PREPARING LIGAND FOR POLYKETONE POLYMERIZATION CATALYST

The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.

POLYKETONE POLYMERIZATION CATALYST

Provided are a novel polyketone polymerization catalyst and a method of preparing a ligand, which can reduce production costs and can enable commercial mass synthesis by using ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine) as a ligand constituting the polykeytone polymerization catalyst, the ligand having a simple structure and a small molecular weight while having high activity.

The influence of OH groups in [Fe(CO)3]2[(μ- ECH2)2C(CH2OH)2] (E = S, Se) complexes toward the cathodic process

[FeFe] hydrogenase model complexes [Fe(CO)3]2[(μ- ECH2)2C(CH2OH)2] (E = S (1) or Se (2)) containing CH2OH bridgehead substituents were synthesized via reaction of equimolar amounts of 4, 4-bis(hydroxymethyl)-1, 2-dithiolane (A) or 4, 4-bis(hydroxymethyl)-1, 2-diselenolane (B) with Fe3(CO) 12 in toluene at 100°C. The presence of OH groups in complexes 1 and 2 is found to influence the cathodic processes and their potentials. The catalytic reduction of acetic acid (AcOH) occurs by the anions 1- and 2-, while the neutral complexes are procatalysts. Copyright

Host-guest complexes of cucurbit[8]uril with some pentaerythritol derivative guests

A series of first generation dendritic guests from pentaerythritol derivatives have been designed and synthesized. Investigation of the complex structures of cucurbit[8]uril (Q[8]) and the guests based on the 1H NMR technique have revealed that the host Q[8] selectively included different branch(es) of the first generation dendritic guests and formed inclusion complexes with different structural conformations. The experimental results obtained from electronic absorption spectroscopy showed that the 1:1 ratio of Q[8]-based host-guest inclusion complexes have moderate stability with an average formation constants of 104 L mol-1. The single crystal structures of some of the guests (g5 and g6) and Q[8]-guest complexes (Q[8]-g4 and Q[8]-g6) further confirm but in some cases contradict the research results of the 1H NMR technique and electronic absorption spectroscopy in aqueous solution. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2011.

Synthesis and characterisation of 2,2-bis(hydroxymethyl)-1,3-diselenolato metal(II) complexes bearing various phosphanes

An improved synthesis of 4,4-bis(hydroxymethyl)-1,2-diselenolane and the complexation properties of the corresponding diselenolato dianion to group-10 metals are reported. We describe an efficient and straightforward procedure that bypasses the isolation of the malodorous and airsensitive diselenol and starts with the diselenide appropriate group-10 metal complex bearing phosphane and chlorido ligands. A series of complexes with various monoand bidentate phosphanes is prepared and characterised by multinuclear NMR spectroscopy, mass spectrometry, and elemental analysis. Furthermore, the structure of most complexes is studied by single-crystal X-ray diffraction to establish their supramolecular arrangement in the solid state. Consequently, several group-10 metal complexes with P-M-P angles (bite angles) in the range from 71-108° are investigated. The use of the sterically demanding bridging phosphane 4,5-bis(diphenylphosphanyl)-9,9-dimethylxanthene, which exhibits a large bite angle yields a mixture of a di- and trinuclear complex. While the platinum-containing complexes are proven to be rather stable, the palladium and nickel analogues tend to decompose. Especially, the nickel complexes were found to be sensitive against: oxidation. This circumstance leads to the formation of the so far unknown 1,8-bis(diphenylphosphanyl)naphthalene monooxide, the formation and structure of which could be confirmed from NMR spectroscopic data and single-crystal X-ray diffraction.

MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS

A class of macrocyclic compounds of formula (I), wherein R7, R9, B, F, M, Q, W, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also p

NOVEL PHOSPHODI ESTERASE INHIBITORS

The present invention relates to a compound according to formula I, wherein X, A, G, E, R1, R2, R3 are as shown herein; and pharmaceutically acceptable salts, hydrates, N-oxides or solvates hereof. The invention further re