3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

Base Information

Chemical Name:3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide
CAS No.:1624606-66-1
Molecular Formula:C₂₄H₂₄F₅N₃O₄
Molecular Weight:513.464
Hs Code.:

Synonyms:3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

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Chemical Property of 3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

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Technology Process of 3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

There total 10 articles about 3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.16%

: 1624605-49-7
N-((4S,6S)-4-(5-bromo-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

: 37143-54-7
methoxyisopropylamine

: 1624606-66-1
3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

Guidance literature:: With palladium diacetate; In hexane; ethyl acetate; toluene;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1624606-66-1
3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

7: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

8: palladium diacetate / ethyl acetate; hexane; toluene

With hydrogenchloride; n-butyllithium; sodium borohydrid; triethanolamine; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; palladium diacetate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; hexane; acetic acid methyl ester; water; ethyl acetate; toluene; acetonitrile;

Reference yield:

: (R,E)-N-(1-(5-bromo-2-fluorophenyl)-2-fluoroethylidene)-2-methylpropane-2-sulfinamide

: 1624606-66-1
3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

2: sodium borohydrid; ammonia / tetrahydrofuran; methanol

3: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

4: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

5: hydrogenchloride / ethyl acetate; 1,4-dioxane

6: dicyclohexyl-carbodiimide; triethanolamine / tetrahydrofuran; ethyl acetate; acetonitrile

7: palladium diacetate / ethyl acetate; hexane; toluene

With hydrogenchloride; n-butyllithium; sodium borohydrid; triethanolamine; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; palladium diacetate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; hexane; acetic acid methyl ester; ethyl acetate; toluene; acetonitrile;