(2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

Base Information

Chemical Name:(2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol
CAS No.:1624605-48-6
Molecular Formula:C₁₁H₁₁BrF₅NO
Molecular Weight:348.11
Hs Code.:

Synonyms:(2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

Chemical Property:

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Technology Process of (2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

There total 7 articles about (2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-N-((2S,4S)-2-(5-bromo-2-fluorophenyl)-1,5,5,5-tetrafluoro-4-hydroxypentan-2-yl)-2-methylpropane-2-sulfinamide

: 1624605-48-6
(2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate;

Reference yield:

: 1600511-51-0
1-(5-bromo-2-fluorophenyl)-2-fluoroethan-1-one

: 1624605-48-6
(2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran; ethyl acetate; water

2: n-butyllithium; ammonium chloride / tetrahydrofuran; acetic acid methyl ester; [⁽²⁾H₆]acetone

3: sodium borohydrid; ammonia / tetrahydrofuran; methanol

4: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

5: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

6: hydrogenchloride / ethyl acetate; 1,4-dioxane

With hydrogenchloride; n-butyllithium; sodium borohydrid; ammonium chloride; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; acetic acid methyl ester; water; ethyl acetate;

Reference yield:

: 1624605-44-2
(S)-methyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)-4-fluorobutanoate

: 1624605-48-6
(2S,4S)-4-amino-4-(5-bromo-2-fluorophenyl)-1,1,1,5-tetrafluoropentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium borohydrid; ammonia / tetrahydrofuran; methanol

2: sodium hydrogencarbonate / [⁽²⁾H₆]acetone

3: tetrabutyl ammonium fluoride; hydrogenchloride / tetrahydrofuran; ethyl acetate

4: hydrogenchloride / ethyl acetate; 1,4-dioxane

With hydrogenchloride; sodium borohydrid; tetrabutyl ammonium fluoride; ammonia; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; [⁽²⁾H₆]acetone; ethyl acetate;