1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol

Base Information

• Chemical Name: 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol
• CAS No.: 1408230-60-3
• Molecular Formula: C₂₃H₂₃N₃O
• Molecular Weight: 357.455
• Mol file: 1408230-60-3.mol

Synonyms:1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol

Chemical Property of 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol

There total 4 articles about 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + calcium carbide (75-20-7) + 3-chloro-N-p-tolylquinoxalin-2-amine (94064-00-3) → 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol (1408230-60-3)

Guidance literature:

cyclohexanone; calcium carbide; With caesium carbonate; In water; dimethyl sulfoxide; at 60 ℃; for 8h;

3-chloro-N-p-tolylquinoxalin-2-amine; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In water; dimethyl sulfoxide; at 60 ℃;

DOI:10.1002/hlca.201800004

Reference yield: 75.0%

1-Ethynylcyclohexan-1-ol (78-27-3) + 3-chloro-N-p-tolylquinoxalin-2-amine (94064-00-3) → 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol (1408230-60-3)

Guidance literature:

3-chloro-N-p-tolylquinoxalin-2-amine; With copper(l) iodide; 10% Pd/C; triethylamine; triphenylphosphine; In toluene; at 25 - 30 ℃; for 0.333333h; Inert atmosphere;

1-Ethynylcyclohexan-1-ol; In toluene; at 20 - 100 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.08.119

Reference yield:

2,3-dichloroquinoxaline (2213-63-0) → 1-[1-(4-methylphenyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]cyclohexanol (1408230-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 10 h / 80 °C / Inert atmosphere

2.1: 10% Pd/C; triethylamine; triphenylphosphine; copper(l) iodide / toluene / 0.33 h / 25 - 30 °C / Inert atmosphere

2.2: 5 h / 20 - 100 °C / Inert atmosphere

With aluminum (III) chloride; copper(l) iodide; 10% Pd/C; triethylamine; triphenylphosphine; In 1,2-dichloro-ethane; toluene;

DOI:10.1016/j.tetlet.2012.08.119

upstream raw materials:

1-Ethynylcyclohexan-1-ol

3-chloro-N-p-tolylquinoxalin-2-amine

2,3-dichloroquinoxaline

p-toluidine