(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

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Chemical Name:(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
CAS No.:121187-66-4
Molecular Formula:C₂₁H₂₆N₆O₅
Molecular Weight:442.475
Hs Code.:

Synonyms:(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

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Chemical Property of (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

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Technology Process of (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

There total 11 articles about (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 121187-76-6
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

: 121187-66-4
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

Guidance literature:: With sodium hydroxide; In methanol; for 5.5h; Ambient temperature;
DOI:10.1002/jhet.5570260247

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 121187-66-4
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 8.7 percent / dimethylsulfoxide / 0.33 h / Heating

2: 62 percent / 1 N HCl, H₂ / 10 percent Pd/C / propan-2-ol; H₂O

3: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C

4: 93 percent / 2,5 N NaOH / methanol / 6 h / Ambient temperature

5: 41 percent / (EtO)2P(O)CN, NEt₃, N-methylpyrrolidin-2-one / dimethylformamide / 29 h / Ambient temperature

6: 100 percent / 1 N NaOH / methanol / 5.5 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; hydrogen; sodium acetate; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/jhet.5570260247

Reference yield:

: 1029-52-3
2-amino-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

: 121187-66-4
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / POCl₃, DMF / 3.5 h / Heating

2: 71 percent / NH₂NH₂ / H₂O; ethanol / 17 h / Ambient temperature

3: 81 percent / 1 N HCl, H₂ / 10 percent Pd/C / ethanol

4: 92 percent / H₂ / Davison sponge nickel / ethanol; H₂O / 22 h

5: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C

6: 93 percent / 2,5 N NaOH / methanol / 6 h / Ambient temperature

7: 41 percent / (EtO)2P(O)CN, NEt₃, N-methylpyrrolidin-2-one / dimethylformamide / 29 h / Ambient temperature

8: 100 percent / 1 N NaOH / methanol / 5.5 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; hydrogen; sodium acetate; triethylamine; N,N-dimethyl-formamide; sodium iodide; hydrazine; trichlorophosphate; palladium on activated charcoal; Davison sponge nickel; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570260247