(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

Base Information

Chemical Name:(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester
CAS No.:121187-76-6
Molecular Formula:C₂₃H₃₀N₆O₅
Molecular Weight:470.528
Hs Code.:

Synonyms:(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

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Chemical Property of (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

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Technology Process of (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

There total 10 articles about (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 121187-75-5
2,4-diamino-6-<2-(4-carboxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

: 121187-76-6
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

Guidance literature:: With 1-methyl-pyrrolidin-2-one; diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 29h; Ambient temperature;
DOI:10.1002/jhet.5570260247

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 121187-76-6
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 8.7 percent / dimethylsulfoxide / 0.33 h / Heating

2: 62 percent / 1 N HCl, H₂ / 10 percent Pd/C / propan-2-ol; H₂O

3: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C

4: 93 percent / 2,5 N NaOH / methanol / 6 h / Ambient temperature

5: 41 percent / (EtO)2P(O)CN, NEt₃, N-methylpyrrolidin-2-one / dimethylformamide / 29 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; hydrogen; sodium acetate; triethylamine; sodium iodide; palladium on activated charcoal; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/jhet.5570260247

Reference yield:

: 1029-52-3
2-amino-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

: 121187-76-6
(S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / POCl₃, DMF / 3.5 h / Heating

2: 71 percent / NH₂NH₂ / H₂O; ethanol / 17 h / Ambient temperature

3: 81 percent / 1 N HCl, H₂ / 10 percent Pd/C / ethanol

4: 92 percent / H₂ / Davison sponge nickel / ethanol; H₂O / 22 h

5: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C

6: 93 percent / 2,5 N NaOH / methanol / 6 h / Ambient temperature

7: 41 percent / (EtO)2P(O)CN, NEt₃, N-methylpyrrolidin-2-one / dimethylformamide / 29 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; hydrogen; sodium acetate; triethylamine; N,N-dimethyl-formamide; sodium iodide; hydrazine; trichlorophosphate; palladium on activated charcoal; Davison sponge nickel; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570260247