benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

Base Information

Chemical Name:benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate
CAS No.:1185571-31-6
Molecular Formula:C₂₄H₂₀F₂N₂O₃
Molecular Weight:422.431
Hs Code.:

Synonyms:benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

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Chemical Property of benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

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Technology Process of benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

There total 4 articles about benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 764645-61-6
4-chlorophenyl 3-(2,4-difluorophenyl)-3-oxo-propanimidothioate

: 3054-11-3
benzyl 4-aminophenylacetate

: 1185571-31-6
benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

Guidance literature:: 4-chlorophenyl 3-(2,4-difluorophenyl)-3-oxo-propanimidothioate; benzyl 4-aminophenylacetate; In acetic acid; at 80 ℃; for 1h;

With sodium hydrogencarbonate; at 20 ℃; for 0.5h;

Reference yield:

: 1185571-27-0
benzyl {4-[(tert-butoxycarbonyl)amino]phenyl}acetate

: 1185571-31-6
benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: acetic acid / 1 h / 80 °C

2.2: 0.5 h / 20 °C

With trifluoroacetic acid; In dichloromethane; acetic acid;

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1185571-31-6
benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 20 °C

1.2: pH 2

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: acetic acid / 1 h / 80 °C

4.2: 0.5 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; acetic acid;