Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

Base Information

Chemical Name:Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester
CAS No.:183274-00-2
Molecular Formula:C₅₅H₆₉N₆O₁₇P
Molecular Weight:1117.16
Hs Code.:

Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

Synonyms:Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

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Chemical Property of Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

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Technology Process of Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

There total 14 articles about Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 183273-99-6
C₆₇H₉₅N₆O₁₈PSi₂

: 183274-00-2
Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/0040-4020(96)00731-4

Reference yield:

: 22634-92-0
4-oxo-heptanedioic acid dimethyl ester

: 183274-00-2
Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 36 percent / LiAlH₄ / diethyl ether / 0.5 h / Heating

2: 78 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

3: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

5: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

6: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

7: pyridine / 1 h / 20 °C

8: 99 percent / NH₃ / methanol / 3 h / 20 °C

9: tetrazole / acetonitrile / 0.75 h / 20 °C

10: aq. I₂, pyridine / tetrahydrofuran / 0.17 h / 20 °C

11: 97 percent / aq. TBAF / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; 1H-tetrazole; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; tetrabutyl ammonium fluoride; ammonia; hydrogen; iodine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4020(96)00731-4

Reference yield:

: 3920-53-4
heptane-1,4,7-triol

: 183274-00-2
Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 78 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

2: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

4: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

5: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

6: pyridine / 1 h / 20 °C

7: 99 percent / NH₃ / methanol / 3 h / 20 °C

8: tetrazole / acetonitrile / 0.75 h / 20 °C

9: aq. I₂, pyridine / tetrahydrofuran / 0.17 h / 20 °C

10: 97 percent / aq. TBAF / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; 1H-tetrazole; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; tetrabutyl ammonium fluoride; ammonia; hydrogen; iodine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4020(96)00731-4