2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

Base Information

Chemical Name:2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide
CAS No.:1356493-29-2
Molecular Formula:C₂₄H₃₁FN₁₀O
Molecular Weight:494.575
Hs Code.:

Synonyms:2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

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Chemical Property of 2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

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Technology Process of 2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

There total 9 articles about 2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1309831-10-4
5-aminocarbonyl-2-chloro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine

: 1356493-51-0
4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

: 1356493-29-2
2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

Guidance literature:: 5-aminocarbonyl-2-chloro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)-4-pyrimidineamine; 4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine; With toluene-4-sulfonic acid; In isopropyl alcohol; at 100 ℃;

With sodium hydroxide; In ethyl acetate; pH=12 - 14;

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 1356493-29-2
2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / ethyl acetate / -30 - -20 °C

1.2: 1.08 h / -20 - -15 °C

2.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

3.1: trimethylsilylazide; acetic acid / 70 °C

3.2: pH 12 - 14

4.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

5.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

5.2: pH 12 - 14

With trimethylsilylazide; sulfuric acid; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 346433-97-4
2-bromo-4-fluoro-5-nitrophenylamine

: 1356493-29-2
2-(4-cyclopropyl-2-fluoro-5-tetrazol-1-yl-phenylamino)-4-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidine-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

2.1: trimethylsilylazide; acetic acid / 70 °C

2.2: pH 12 - 14

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

4.2: pH 12 - 14

With trimethylsilylazide; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; isopropyl alcohol; toluene;