4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

Base Information

Chemical Name:4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine
CAS No.:1356493-51-0
Molecular Formula:C₁₀H₁₀FN₅
Molecular Weight:219.221
Hs Code.:

Synonyms:4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

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Technology Process of 4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

There total 4 articles about 4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1356493-50-9
1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-1H-tetrazole

: 1356493-51-0
4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; water; acetic acid; under 1551.49 Torr;

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 1356493-51-0
4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / ethyl acetate / -30 - -20 °C

1.2: 1.08 h / -20 - -15 °C

2.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

3.1: trimethylsilylazide; acetic acid / 70 °C

3.2: pH 12 - 14

4.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

With trimethylsilylazide; sulfuric acid; hydrogen; caesium carbonate; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; ethyl acetate; toluene;

Reference yield:

: 346433-97-4
2-bromo-4-fluoro-5-nitrophenylamine

: 1356493-51-0
4-cyclopropyl-2-fluoro-5-(1H-tetrazol-l-yl)benzeneamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

2.1: trimethylsilylazide; acetic acid / 70 °C

2.2: pH 12 - 14

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

With trimethylsilylazide; hydrogen; caesium carbonate; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; toluene;