(1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

Base Information

Chemical Name:(1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol
CAS No.:322407-39-6
Molecular Formula:C₂₅H₂₇NO₃S
Molecular Weight:421.56
Hs Code.:

Synonyms:(1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

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Chemical Property of (1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

Chemical Property:

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Technology Process of (1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

There total 6 articles about (1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 98-09-9
benzenesulfonyl chloride

: 322407-37-4
(1R,2R)-trans-2-[N-(4-phenylbenzyl)]aminocyclohexanol

: 322407-39-6
(1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4.3h;
DOI:10.1016/S0957-4166(00)00340-2

Reference yield:

: 931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5
(1R,2R)-2-aminocyclohexanol

: 322407-39-6
(1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 91 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: 95 percent / Et₃N / CH₂Cl₂ / 4.3 h / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(00)00340-2

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 322407-39-6
(1R,2R)-trans-20-[N-benzenesulfonyl-N-(4-phenylbenzyl)]aminocyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Me₃Al / CH₂Cl₂; hexane / 1 h / 0 °C

1.2: 45 percent / CH₂Cl₂ / 21 h / 0 - 20 °C

2.1: 78 percent / H₂ / 10 percent Pd/C / methanol / 72 h / 20 °C

3.1: 86 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: 91 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

5.1: 95 percent / Et₃N / CH₂Cl₂ / 4.3 h / 0 - 20 °C

With lithium aluminium tetrahydride; hydrogen; trimethylaluminum; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/S0957-4166(00)00340-2