1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide

Base Information

• Chemical Name: 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide
• CAS No.: 1380204-02-3
• Molecular Formula: C₁₈H₁₇BrN₆O₂
• Molecular Weight: 429.276
• Mol file: 1380204-02-3.mol

Synonyms:1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide

Chemical Property of 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide

There total 6 articles about 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(5-bromo-3-formyl-2-hydroxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide (1380204-01-2) + malononitrile (109-77-3) → 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide (1380204-02-3)

Guidance literature:

With piperidine; In ethanol; at 20 ℃;

DOI:10.1039/c2ob25304f

Reference yield:

(3-azidomethyl-5-bromo-2-methoxyphenyl)methanol (1380203-97-3) → 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide (1380204-02-3)

Guidance literature:

Multi-step reaction with 5 steps

1: copper(ll) sulfate pentahydrate; sodium ascorbate / ethanol; water / 24 h / 20 °C

2: 4 h / 70 °C

3: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

5: piperidine / ethanol / 20 °C

With piperidine; copper(ll) sulfate pentahydrate; sodium ascorbate; boron tribromide; pyridinium chlorochromate; In ethanol; dichloromethane; water;

DOI:10.1039/c2ob25304f

Reference yield:

1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (1380203-98-4) → 1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide (1380204-02-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 4 h / 70 °C

2: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: piperidine / ethanol / 20 °C

With piperidine; boron tribromide; pyridinium chlorochromate; In ethanol; dichloromethane;

DOI:10.1039/c2ob25304f

upstream raw materials:

(3-azidomethyl-5-bromo-2-methoxyphenyl)methanol

1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide

1-(5-bromo-3-formyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide