1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester
• CAS No.: 1380203-98-4
• Molecular Formula: C₁₃H₁₄BrN₃O₄
• Molecular Weight: 356.176
• Mol file: 1380203-98-4.mol

Synonyms:1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Chemical Property of 1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

There total 1 articles about 1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3-azidomethyl-5-bromo-2-methoxyphenyl)methanol (1380203-97-3) + propynoic acid methyl ester (922-67-8) → 1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (1380203-98-4)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium ascorbate; In ethanol; water; at 20 ℃; for 24h;

DOI:10.1039/c2ob25304f

Reference yield: 94.0%

1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (1380203-98-4) + N-butylamine (109-73-9,85404-21-3) → 1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide (1380203-99-5)

Guidance literature:

at 70 ℃; for 4h;

DOI:10.1039/c2ob25304f

Reference yield:

1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (1380203-98-4) → 1-(5-bromo-3-formyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide (1380204-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 h / 70 °C

2: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

With pyridinium chlorochromate; In dichloromethane;

DOI:10.1039/c2ob25304f

upstream raw materials:

(3-azidomethyl-5-bromo-2-methoxyphenyl)methanol

propynoic acid methyl ester

Downstream raw materials:

1-(5-bromo-3-formyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide

1-(5-bromo-3-formyl-2-hydroxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide

1-[5-bromo-3-(2,2-dicyanovinyl)-2-hydroxybenzyl]-1H-[1,2,3]triazole-4-carboxylic acid butylamide

1-(5-bromo-3-hydroxymethyl-2-methoxybenzyl)-1H-[1,2,3]triazole-4-carboxylic acid butylamide