4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

Base Information

Chemical Name:4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid
CAS No.:168542-18-5
Molecular Formula:C₁₅H₁₀FNO₃S
Molecular Weight:303.314
Hs Code.:

Synonyms:4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

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Chemical Property of 4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

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Technology Process of 4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

There total 7 articles about 4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 168542-22-1
4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid ethyl ester

: 168542-18-5
4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 2h; Heating;
DOI:10.1248/cpb.45.1642

Reference yield:

: 462-06-6
fluorobenzene

: 168542-18-5
4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / AlCl₃ / 3.5 h / Heating

2: DMF, oxalyl chloride / tetrahydrofuran / 30 h / Ambient temperature

3: Et₃N / tetrahydrofuran / 2 h / Ambient temperature

4: 38 percent / DBU / toluene / 3 h / Heating

5: 86 percent / 1N aq. NaOH / methanol; tetrahydrofuran / 2 h / Heating

With sodium hydroxide; aluminium trichloride; oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; toluene;
DOI:10.1248/cpb.45.1642

Reference yield:

: 6007-83-6
2,3-thiophenedicarboxylic acid anhydride

: 168542-18-5
4-(4-fluorophenyl)-6,7-dihydro-6-methyl-7-oxo-5-thieno[2,3-c]pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / AlCl₃ / 3.5 h / Heating

2: DMF, oxalyl chloride / tetrahydrofuran / 30 h / Ambient temperature

3: Et₃N / tetrahydrofuran / 2 h / Ambient temperature

4: 38 percent / DBU / toluene / 3 h / Heating

5: 86 percent / 1N aq. NaOH / methanol; tetrahydrofuran / 2 h / Heating

With sodium hydroxide; aluminium trichloride; oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; toluene;
DOI:10.1248/cpb.45.1642