METHYL 3-(2-CHLORO-6-FLUOROPHENYL)-5-[2-(DIMETHYLAMINO)VINYL]-4-ISOXAZOLECARBOXYLATE

Base Information

• Chemical Name: METHYL 3-(2-CHLORO-6-FLUOROPHENYL)-5-[2-(DIMETHYLAMINO)VINYL]-4-ISOXAZOLECARBOXYLATE
• CAS No.: 338417-50-8
• Molecular Formula: C₁₅H₁₄ClFN₂O₃
• Molecular Weight: 324.739
• Hs Code.: 2934999090
• Mol file: 338417-50-8.mol

Synonyms:methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate

Chemical Property of METHYL 3-(2-CHLORO-6-FLUOROPHENYL)-5-[2-(DIMETHYLAMINO)VINYL]-4-ISOXAZOLECARBOXYLATE

Chemical Property:

• Melting Point: 139-141°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 3-(2-chloro-6-fluorophenyl)-5-[2-(dimethyl-amino)vinyl]-4-isoxazolecarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(2-CHLORO-6-FLUOROPHENYL)-5-[2-(DIMETHYLAMINO)VINYL]-4-ISOXAZOLECARBOXYLATE

There total 1 articles about METHYL 3-(2-CHLORO-6-FLUOROPHENYL)-5-[2-(DIMETHYLAMINO)VINYL]-4-ISOXAZOLECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

tert-Butoxybis(dimethylamino)methane (5815-08-7) + methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (4415-09-2) → methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (338417-50-8)

Guidance literature:

In toluene; for 6h; Reflux;

Reference yield: 94.0%

methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (338417-50-8) + trifluoroacetic anhydride (407-25-0) → methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(dimethylamino)-4,4,4-trifluoro-3-oxobut-1-en-2-yl)isoxazole-4-carboxylate (338966-53-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

methyl 3-(2-chloro-6-fluorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate (338417-50-8) → 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-N-methoxy-N-methylisoxazole-4-carboxamide (1391943-30-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane / 3 h / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / Reflux

3.1: sodium hydroxide; water / ethanol / Reflux

3.2: pH 1

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-Butoxybis(dimethylamino)methane

methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate

Downstream raw materials:

methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(dimethylamino)-4,4,4-trifluoro-3-oxobut-1-en-2-yl)isoxazole-4-carboxylate

methyl 3-(2-chloro-6-fluorophenyl)-5-{[1-(4-methoxycarbonyl-3-(4-chlorophenyl)isoxazol-5-yl)-5-trifluoromethyl-1H-pyrazol-4-yl]}-isoxazole-4-carboxylate

3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-N-methoxy-N-methylisoxazole-4-carboxamide

3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxamide

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