Technology Process of benzyl 1,2-dihydro-3-methyl-1-oxoisoquinoline-4-carboxylate
There total 5 articles about benzyl 1,2-dihydro-3-methyl-1-oxoisoquinoline-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzamide;
With
dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate;
In
1,2-dichloro-ethane;
at 20 ℃;
for 0.0833333h;
Sealed tube;
benzyl-α-diazo-acetoacetate;
In
1,2-dichloro-ethane;
at 100 ℃;
for 7h;
Inert atmosphere;
DOI:10.1021/acs.joc.5b02824
- Guidance literature:
-
With
copper(l) iodide; caesium carbonate;
In
1,4-dioxane;
at 80 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/ol900847t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ammonium hydroxide / dichloromethane / 0.5 h / Cooling with ice
2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate / 1,2-dichloro-ethane / 0.08 h / 20 °C / Sealed tube
2.2: 7 h / 100 °C / Inert atmosphere
With
ammonium hydroxide; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate;
In
dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/acs.joc.5b02824
