ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

Base Information

Chemical Name:ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate
CAS No.:1290127-98-8
Molecular Formula:C₁₈H₁₉BrN₂O₅S
Molecular Weight:455.329
Hs Code.:

Synonyms:ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

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Chemical Property of ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

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Technology Process of ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

There total 6 articles about ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 3-bromo-5-({2-[(2,6-dimethoxy-4-methoxymethyl)phenyl]-2-oxoethyl}thio)-1-(methoxymethyl)-1H-pyrazole-4-carboxylate

: 1290127-98-8
ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; for 20h; Reflux;

Reference yield:

: 37622-90-5
4-ethoxycarbonylpyrazole

: 1290127-98-8
ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; bromine / ethanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Cooling with ice

3.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 90 °C

3.2: 2 h / 20 °C

4.1: hydrogenchloride / isopropyl alcohol; water / 20 h / Reflux

With hydrogenchloride; sodium sulfide; bromine; sodium acetate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1190854-45-5
1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]ethanone

: 1290127-98-8
ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; t-butyldimethylsiyl triflate / tetrahydrofuran / Cooling with ice

1.2: 1.5 h

1.3: Cooling with ice

2.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 90 °C

2.2: 2 h / 20 °C

3.1: hydrogenchloride / isopropyl alcohol; water / 20 h / Reflux

With hydrogenchloride; sodium sulfide; t-butyldimethylsiyl triflate; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;