3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

Base Information

Chemical Name:3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole
CAS No.:1290128-01-6
Molecular Formula:C₁₆H₁₈N₂O₅S₂
Molecular Weight:382.461
Hs Code.:

Synonyms:3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

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Chemical Property of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

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Technology Process of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

There total 6 articles about 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290128-00-5
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

: 20277-69-4
sodium methansulfinate

: 1290128-01-6
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: With copper(l) iodide; L-proline; sodium hydroxide; In dimethyl sulfoxide; at 140 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1290128-06-1
2-bromo-1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]ethanone

: 1290128-01-6
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 90 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / isopropyl alcohol; water / 20 h / Reflux

3.1: sodium hydroxide; water / ethanol / 2 h / Reflux

3.2: Cooling with ice

4.1: hydrogenchloride / 1,4-dioxane; water / 13 h / Reflux

5.1: L-proline; sodium hydroxide; copper(l) iodide / dimethyl sulfoxide / 3 h / 140 °C / Microwave irradiation

With hydrogenchloride; sodium sulfide; copper(l) iodide; water; L-proline; sodium hydroxide; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1290127-99-9
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylic acid

: 1290128-01-6
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-(methylsulfonyl)pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 13 h / Reflux

2: L-proline; sodium hydroxide; copper(l) iodide / dimethyl sulfoxide / 3 h / 140 °C / Microwave irradiation

With hydrogenchloride; copper(l) iodide; L-proline; sodium hydroxide; In 1,4-dioxane; water; dimethyl sulfoxide;