6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

Base Information

Chemical Name:6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole
CAS No.:1290128-00-5
Molecular Formula:C₁₅H₁₅BrN₂O₃S
Molecular Weight:383.266
Hs Code.:

Synonyms:6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

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Chemical Property of 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

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Technology Process of 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

There total 5 articles about 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290127-99-9
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylic acid

: 1290128-00-5
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; for 13h; Reflux;

Reference yield:

: 1290127-98-8
ethyl 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylate

: 1290128-00-5
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 2 h / Reflux

1.2: Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane; water / 13 h / Reflux

With hydrogenchloride; water; sodium hydroxide; In 1,4-dioxane; ethanol; water;

Reference yield:

: 1190854-45-5
1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]ethanone

: 1290128-00-5
6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; t-butyldimethylsiyl triflate / tetrahydrofuran / Cooling with ice

1.2: 1.5 h

1.3: Cooling with ice

2.1: sodium sulfide / N,N-dimethyl-formamide / 2 h / 90 °C

2.2: 2 h / 20 °C

3.1: hydrogenchloride / isopropyl alcohol; water / 20 h / Reflux

4.1: sodium hydroxide; water / ethanol / 2 h / Reflux

4.2: Cooling with ice

5.1: hydrogenchloride / 1,4-dioxane; water / 13 h / Reflux

With hydrogenchloride; sodium sulfide; t-butyldimethylsiyl triflate; water; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;