ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Chemical Name:ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
CAS No.:858358-78-8
Molecular Formula:C₂₃H₁₈F₃N₃O₂
Molecular Weight:425.41
Hs Code.:

Synonyms:ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Chemical Property of ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Technology Process of ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

There total 3 articles about ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 114084-99-0
2-phenylamino-6-phenyl-4-trifluoromethylnicotinonitrile

: 105-36-2
ethyl bromoacetate

: 858358-78-8
ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 8h;
DOI:10.3987/COM-05-10334

Reference yield:

: 858358-62-0
2-iodo-6-phenyl-4-trifluoromethylnicotinonitrile

: 858358-78-8
ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 6 h / 110 °C

2: 76 percent / K₂CO₃; NaI / dimethylformamide / 8 h / 120 °C

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; 2: Thorpe-Ziegler reaction;
DOI:10.3987/COM-05-10334

Reference yield:

: 114085-00-6
2-amino-3-cyano-4-trifluoro-methyl-6-phenyl-pyridine

: 858358-78-8
ethyl 3-amino-1,6-diphenyl-4-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaNO₂; HCl / acetonitrile; H₂O / 0 - 5 °C

1.2: 82 percent / KI / acetonitrile; H₂O / 3 h / 20 °C

2.1: 84 percent / 6 h / 110 °C

3.1: 76 percent / K₂CO₃; NaI / dimethylformamide / 8 h / 120 °C

With hydrogenchloride; potassium carbonate; sodium iodide; sodium nitrite; In water; N,N-dimethyl-formamide; acetonitrile; 1.1: Sandmeyer reaction / 3.1: Thorpe-Ziegler reaction;
DOI:10.3987/COM-05-10334